Cbz-B3A
产品描述
Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appears to bind to ubiquitin 1, 2, and 4. It inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).
体外活性 Cbz-B3A has a larger effect on the phosphorylation of 4EBP1 than p70S6k compared to rapamycin. Cbz-B3A inhibits mTOR through Ubiquilins. Cbz-B3A slows cellular growth of some human leukemia cell lines but is not cytotoxic. Cbz-B3A decreases the incorporation of [35S]methionine/cysteine into protein in a dose-dependent manner, with maximal inhibition of 68% observed at 10 μM (EC50: ~3 μM).
分子量 706.87
分子式 C35H58N6O9
CAS No. 1884710-81-9
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
( < 1 mg/mL refers to the product slightly soluble or insoluble )
本产品只适用于科研,不能用于临床诊断。严禁用于临床医疗及其他非科研用途!
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